ABOUT PROFESSOR PROFYRIS

Professor Christos Profyris completed his pre-clinical medical studies at the University of Cambridge with a Double First Class and went on to finish his medical degree with Distinction at the University of Oxford. He completed his Neurosurgical training at the University of Witwatersrand and achieved his Neurosurgery Fellowship qualification from the College of Medicine of South Africa. Finally, he also holds a Master of Medicine in Neurosurgery from the University of Witwatersrand.

In 2019, Professor Christos Profyris completed the prestigious Charles Teo Minimally Invasive Neurosurgery Fellowship under Professor Charles Teo at the Centre for Minimally Invasive Neurosurgery in Sydney. Professor Teo is a world expert in brain tumour surgery having operated on more than 11,000 brain tumours, he was a Professor in the United States for 10 years and is a visiting Professor at DUKE University. He has pioneered keyhole and minimally invasive brain surgery techniques and has more than 100 publication. Professor Christos Profyris had the privilege of learning Professor Teo's techniques and gaining a more in-depth understanding of keyhole techniques and brain tumour surgery.

Professor Christos Profyris heads the Helen Joseph Hospital Neurosurgery Department, where he focuses on brain tumour surgery and vascular neurosurgery.

PUBLICATIONS:

• Van Eck D et al. Calvarial Hyperpigmentation. Surg. Neurol. Int. Accepted Manuscript – 21 July 2023
• Naicker D et al. Single Surgeon Series of myelomeningocoele repair in a developing world setting: Challenges and lessons. World Neurosurg. X. 2023 May 19; 19:100213
• Ndlovu B et al. Supraorbital eyebrow approach: a single center experience. Surg. Neurol. Int. 2022 Dec 2; 13:566 – Senior author article
• Mohale DG et al. Keyhole approaches applied to clipping of acutely ruptured intracerebral aneurysms - A technical note and case series. World Neurosurg. 2022 Oct 13;168:209-218. – Senior author article
• Ndlovu B. et al. Ruptured presentation of superficial temporal artery pseudoaneurysm treated with anastomotic repair: Case report. 2022 Jan 26;38:100615 – Senior author article
• Profyris C. et al. Anaplastic oligodendroglioma – Is adjuvent radiotherapy mandatory following maximal surgical resection?: Grade 3 Oligo Radiotherapy. Clin Neurol Neurosurg. 2021 Jan; 200:106303
• Profyris C. Brain tumours: an update. Neuron SA. 2019 12(1) issue 38: 10-12
• Profyris C. et al. Cutaneous scarring: pathophysiology, molecular mechanisms and scar reduction therapeutics Part I. J Am Acad Dermatol. 2012 Jan;66(1): 1-10; quiz 11-2. Review
• Profyris C. et al. Delayed management of penetrating cardiac injury – less urgency, more options. Injury Extra. 2011 Aug;42(8):83-84
• Profyris C. et al. Solitary fibrous tumour of the face: A rare case report. J Plast, Reconstr & Aesthet Surg. 2010 Jan;63(1):e13-5
• Profyris C. et al. Degenerative and regenerative mechanisms governing spinal cord injury. Neurobiol Dis. 2004 Apr;15(3):415-36. Review (Citations: 442)
• Anavi K et al. Paravertebral paraganglioma with spinal extension: a case report. J Med Case Rep. 2023 Jun 8;17(1): 234
• Osipowicz K et al. Real world demonstration of hand motor mapping using the structural connectivity atlas. Clin Neurol Neurosurg. 2023 Mar 16;228:107679
• Poologaindran A. et al. Interventional neurorehabilitation for promoting functional recovery post-craniotomy: a proof-of-concept. Sci Rep. 2022 Feb; 23;12(1):3039.
• Poologaindran A et al. 4.A The neuroplastic potential of the human brain before and after glioma surgery: towards interventional neurorehabilitation. Neuro-Onc. 2021 Sep; 23(2) ii16
• Yeung JT. et al. Resection of symptomatic pineal cyst provides durable clinical mprovement: A breakdown of presenting symptoms and lessons learned. World Neurosurg. 2021 Jun; 150:e668-e674.
• Bromfield M. et al. Papillary tumour of the pineal region: a case report. The Egypt. J of Neurol., Psych. And Neurosurg. 2020 56; 55.
• Ahsan SA. et al. Pharmacotherapeutic options for atypical meningiomas. Expert Opin Pharmacother. 2019 Oct; 20(15): 1831-1836
• Tziotzios C. et al. Evidence for fractional laser treatment in the improvement of cutaneuous scars Reply. J Am. Acad Dermatol. 2012 Jan;66(6): 1006-1007
• Tziotzios C. et al. Cutaneous scarring: pathophysiology, molecular mechanisms and scar reduction therapeutics part II. J Am Acad Dermatol 2012 Jan;66(1): 13-24; quiz 25-26. Review
• Azari MF. et al. LIF treatment reduces Nogo-A deposits in spinal cord injury modulating Rho GTPase activity and CRMP-2 phosphorylation. J Neurodegen. & Regen. 2008 1(1): 23-29
• Azari MF. et al. Leukemia inhibitory factor arrests oligodendrocyte death and demyelination in spinal cord injury. J Neuropathol Exp Neurol. 2006 Sep;65(9):914-29.2008
• Petratos S. et al. Expression of the low-affinity neurotrophin receptor, p75(NTR), is upregulated by oligodendroglial progenitors adjacent to the subventricular zone in response to demyelination. Glia. 2004 Oct;48(1):64-75
• Boyle K. et al. Molecular mechanisms in Schwann cell survival and death during peripheral nerve development, injury and disease.Neurotox Res. 2005;7(1-2):151-67. Review.
• Azari MF. et al. Effects of intraperitoneal injection of Rofecoxib in a mouse model of ALS.Eur J Neurol. 2005 May;12(5):357-64.
• Azari MF. et al. Induction of endogenous neural precursors in mouse models of spinal cord injury and disease. Eur J Neurol. 2005 Aug;12(8):638-48.
• Azari MF. et al. Incomplete Freund's adjuvant enhances locomotor performance following spinal cord injury. Eur J Neurol. 2005 Dec;12(12):1004-8

INVITED PRESENTATIONS

• 2023 Aug - South African Neurosurgical Society (SNSA) Virtual Grand Round Series Presentation_Tuberculum Sellae Meningioma – Endoscopic Applications
• 2023 Jul – Society of Neuroscientists of Africa 16th International Congress_The Human Connectome and Applications
• 2023 Jun – Medicross Clinical Webinar Series_Brain Mapping and Transcranial Magnetic Stimulation Applications
• 2023 Feb – Complications in Meningioma Surgery Symposium by Crossroads_Keyhole Approaches in meningioma surgery lecture
• 2023 Feb – Course Director of Advanced Neurosurgical Anatomy Hands-on Cadaver Course_Part 3 Cranial Nerve Anatomy_Wits Surgical Skills Lab: Johannesburg
• 2022 Nov – Course Director of Advanced Neurosurgical Anatomy Hands-on Cadaver Course_Part 2 Posterior Arterial Circulation and Cerebral Venous Anatomy_Wits Surgical Skills Lab: Johannesburg
• 2022 Nov - South African Neurosurgical Society (SNSA) Virtual Grand Round Series Presentation_ACOM aneurysm Clipping – How I do it
• 2022 Oct – South African Neurosurgical Society (SNSA) Congress Platform Presentation_Transorbital Approach: Personal Surgical Case Series
• 2022 Oct – South African Neurosurgical Society (SNSA) Congress Platform Presentation_ Review of last 100 Endoscopic Cranial Surgical Cases
• 2022 Oct – South African Neurosurgical Society (SNSA) Congress Flash Presentation_ Transcranial Magnetic Stimulation: Pre-Operative and Post-Operative Use-Case in Neuro-Oncology
• 2022 Oct – South African Neurosurgical Society (SNSA) Congress Flash Presentation_Review of Endoscopic Resection of Colloid Cysts: Personal Case Series
• 2022 Jun – Rand Merchant Bank Healthcare Innovation Forum – The Systemic Mental Health Challenge Presentation_ Applying Personalised Brain Mapping to the Treatment of Mental Health Conditions with Transcranial Magnetic Stimulation
• 2022 May – Course Director of Advanced Neurosurgical Anatomy Hands-on Cadaver Course_Part 1 Anterior Cerebral Circulation_Wits Surgical Skills Lab: Johannesburg
• 2022 Apr – South African Neurosurgical Society (SNSA) Virtual Grand Round Series Presentation_Orbital Tumours: Anatomy, Pathology and Personal Case Series
• 2022 Apr – Clinix Health Group Webinar Presentation_The future of Brain tumour surgery
• 2022 Mar – Wits Sports an Health (WiSH) Congress Platform Presentation_Brain Mapping and Concussion
• 2021 Nov – Clinical TMS Society November Grand Round Webinar_The Connectome Revolution and TMS Applications
• 2021 Oct – South African Neurosurgical Society (SNSA) Congress Platform Presentation_Personal Surgical Case Series of Keyhole Approaches Applied to Clipping of Acutely Ruptured Intracerebral Aneurysms
• 2021 Oct – South African Neurosurgical Society (SNSA) Congress Platform Presentation_Extended Endoscopic Endonasal Techniques in the Treatment of Giant Pituitary Adenomas: Personal Series
• 2021 Oct – South African Neurosurgical Society (SNSA) Congress Flash Presentation_ Keyhole Supraorbital Approach_Techniques and Applications
• 2021 Oct – South African Neurosurgical Society (SNSA) Congress Platform Presentation_Tractographic Planning Applied to Glioma Surgery
• 2021 Oct – South African Neurosurgical Society (SNSA) Congress Platform Presentation_The Connectome: Neurosurgical Applications
• 2021 Oct – South African Neurosurgical Society (SNSA) Congress Flash Presentation_Treatment of Hemifacial Spasm via Microvascular Decompression_Personal Series.
• 2021 Jul – Wits Sport and Health (WiSH) Monthly Webinar_Brain Mapping and Connectomics in the Context of Concussion
• 2021 Jun – International Neurosurgery Symposiym – Vascular Neurosurgery Updates Webinar(India)_Keyhole Approaches Applied to Cerebral Aneurysm Surgery
• 2021 Apr – The Connectome Revolution Webinar Lecture Series_Episode 6: The Connectome in Disease and TMS Applications
• 2021 Apr – The Connectome Revolution Webinar Lecture Series_Episode 5: Parietal and Occipital Lobe Parcellation Map
• 2021 Apr – The Connectome Revolution Webinar Lecture Series_Episode 4: Temporal Lobe, Insula and Opercula Parcellation Map
• 2021 Apr – The Connectome Revolution Webinar Lecture Series_Episode 3: Frontal Lobe Parcellation Map
• 2021 Apr – The Connectome Revolution Webinar Lecture Series_Episode 2: Brain Architectonics, Development, Graph Theory and Tracts
• 2021 Apr – The Connectome Revolution Webinar Lecture Series_Episode 1: An Introduction to Connectomics

SEMINARS/WORKSHOPS

2019

• State-of-the-Art Endoscopic Skull Base Surgery: A Hands-On Course : Ohio, United States
• Pacific Rim Master Class in Endoscopic Endonasal and Keyhole Surgery : California, United States

2018

• Seventh annual world course in brain tumour surgery : London, United Kingdom
• Multiportal approaches to the skull base - 2nd International Hands-on Course : Vienna, Austria